HIGH CONSTANT INCIDENCE RATES OF SECOND PRIMARY CANCERS OF THE HEAD AND NECK: A POOLED ANALYSIS OF 13 CANCER REGISTRIES
Identifieur interne : 006F46 ( Main/Exploration ); précédent : 006F45; suivant : 006F47HIGH CONSTANT INCIDENCE RATES OF SECOND PRIMARY CANCERS OF THE HEAD AND NECK: A POOLED ANALYSIS OF 13 CANCER REGISTRIES
Auteurs : Cristina Bosetti [Italie] ; Ghislaine Scelo [France] ; Shu-Chun Chuang [France, Royaume-Uni] ; Jon M. Tonita [Canada] ; Sharon Tamaro [Canada] ; Jon G. Jonasson [Islande] ; Erich V. Kliewer [Canada] ; Kari Hemminki [Allemagne, Suède] ; Elisabete Weiderpass [Norvège, Suède, Finlande] ; Eero Pukkala [Finlande] ; Elizabeth Tracey [Australie] ; Jorgen H. Olsen [Danemark] ; Vera Pompe-Kirn [Slovénie] ; David H. Brewster [Royaume-Uni] ; Carmen Martos [Espagne] ; Kee-Seng Chia [Singapour] ; Paul Brennan [France] ; Mia Hashibe [France, États-Unis] ; Fabio Levi [Suisse] ; Carlo La Vecchia [Italie] ; Paolo Boffetta [France, États-Unis]Source :
- International journal of cancer. Journal international du cancer [ 0020-7136 ] ; 2010.
Abstract
Scanty data are available on the incidence (i.e., the absolute risk) of second cancers of the head and neck (HN) and its pattern with age. We investigated this issue using data from a multicentric study of 13 population-based cancer registries from Europe, Canada, Australia and Singapore for the years 1943-2000. A total of 99,257 patients had a first primary HN cancer (15,985 tongue, 22,378 mouth, 20,758 pharyngeal, and 40,190 laryngeal cancer), contributing to 489,855 person-years of follow-up. 1294 of the patients (1.3%) were diagnosed with second HN cancers (342 tongue, 345 mouth, 418 pharynx, and 189 larynx). Male incidence rates of first HN cancer steeply increased from 0.68/100,000 at age 30-34 to 46.2/100,000 at age 70-74, and leveled off at higher age; female incidence increased from 0.50/100,000 at age 30-34 to 16.5/100,000 at age 80-84. However, age-specific incidence of second HN cancers after a first HN cancer in men was around 200-300/100,000 between age 40-44 and age 70-74, and tended to decline at subsequent ages (150/100,000 at age 80-84); in women, incidence of second HN cancers was around 200-300/100,000 between age 45-49 and 80-84. The patterns of age-specific incidence were consistent for different subsites of second HN cancer and sexes; moreover, they were similar for age-specific incidence of first primary HN cancer in patients who subsequently developed a second HN cancer. The incidence of second HN cancers does not increase with age, but remains constant, or if anything, decreases with advancing age.
While the incidence of first primary cancers of the head and neck increases with advancing age that of second primary cancers is stable between age 40 and 70 and, if anything, declines thereafter.
Url:
DOI: 10.1002/ijc.25652
PubMed: 20824702
PubMed Central: 3037425
Affiliations:
- Allemagne, Australie, Canada, Danemark, Espagne, Finlande, France, Islande, Italie, Norvège, Royaume-Uni, Singapour, Slovénie, Suisse, Suède, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Canton de Vaud, District de Karlsruhe, Grand Londres, Hovedstaden, Lombardie, Manitoba, Rhône-Alpes, Svealand, Utah, État de New York
- Copenhague, Heidelberg, Lausanne, Londres, Lyon, Milan, Stockholm, Winnipeg
- Université du Manitoba
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type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Hashibe, Mia" sort="Hashibe, Mia" uniqKey="Hashibe M" first="Mia" last="Hashibe">Mia Hashibe</name><affiliation wicri:level="3"><nlm:aff id="A2">International Agency for Research on Cancer (IARC), Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A25">University of Utah, School of Medicine, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah, School of Medicine, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Levi, Fabio" sort="Levi, 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Farmacologiche “Mario Negri”, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerche Farmacologiche “Mario Negri”, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A27">Dipartimento di Medicina del Lavoro, Sezione di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina del Lavoro, Sezione di Statistica Medica e Biometria, Università degli Studi di Milano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation wicri:level="3"><nlm:aff id="A2">International Agency for Research on Cancer (IARC), Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">International Prevention Research Institute, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Prevention Research Institute, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Tisch Cancer Institute, 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nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name><affiliation wicri:level="3"><nlm:aff id="A2">International Agency for Research on Cancer (IARC), Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Chuang, Shu Chun" sort="Chuang, Shu Chun" uniqKey="Chuang S" first="Shu-Chun" last="Chuang">Shu-Chun Chuang</name><affiliation wicri:level="3"><nlm:aff id="A2">International Agency for Research on Cancer (IARC), Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3">Imperial College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tonita, Jon M" sort="Tonita, Jon M" uniqKey="Tonita J" first="Jon M." last="Tonita">Jon M. Tonita</name><affiliation wicri:level="1"><nlm:aff id="A4">Saskatchewan Cancer Agency, Regina, Saskatchewan, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Saskatchewan Cancer Agency, Regina, Saskatchewan</wicri:regionArea><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Tamaro, Sharon" sort="Tamaro, Sharon" uniqKey="Tamaro S" first="Sharon" last="Tamaro">Sharon Tamaro</name><affiliation wicri:level="1"><nlm:aff id="A5">British Columbia Cancer Agency, Vancouver, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>British Columbia Cancer Agency, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Jonasson, Jon G" sort="Jonasson, Jon G" uniqKey="Jonasson J" first="Jon G." last="Jonasson">Jon G. Jonasson</name><affiliation wicri:level="1"><nlm:aff id="A6">Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Kliewer, Erich V" sort="Kliewer, Erich V" uniqKey="Kliewer E" first="Erich V." last="Kliewer">Erich V. Kliewer</name><affiliation wicri:level="1"><nlm:aff id="A5">British Columbia Cancer Agency, Vancouver, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>British Columbia Cancer Agency, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Epidemiology and Cancer Registry, CancerCare Manitoba, Winnipeg, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Epidemiology and Cancer Registry, CancerCare Manitoba, Winnipeg</wicri:regionArea><wicri:noRegion>Winnipeg</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A9">Community Health Sciences, University of Manitoba, Winnipeg, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Community Health Sciences, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Hemminki, Kari" sort="Hemminki, Kari" uniqKey="Hemminki K" first="Kari" last="Hemminki">Kari Hemminki</name><affiliation wicri:level="3"><nlm:aff id="A10">Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Center for Family and Community Medicine, Karolinska Institutet, Huddinge, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Family and Community Medicine, Karolinska Institutet, Huddinge</wicri:regionArea><wicri:noRegion>Huddinge</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Center for Primary Health Care Research, Lund University, Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Center for Primary Health Care Research, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:aff id="A13">The Cancer Registry of Norway, Oslo, and Department of Community Medicine, Tromso, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>The Cancer Registry of Norway, Oslo, and Department of Community Medicine, Tromso</wicri:regionArea><wicri:noRegion>Tromso</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Samfundet Folkhalsan, Department of Genetic Epidemiology, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Samfundet Folkhalsan, Department of Genetic Epidemiology, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Pukkala, Eero" sort="Pukkala, Eero" uniqKey="Pukkala E" first="Eero" last="Pukkala">Eero Pukkala</name><affiliation wicri:level="1"><nlm:aff id="A16">Finnish Cancer Registry, Institute for Statistical and Epidemiology Cancer Research, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Cancer Registry, Institute for Statistical and Epidemiology Cancer Research, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">School of Public Health, University of Tampere, Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>School of Public Health, University of Tampere, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Tracey, Elizabeth" sort="Tracey, Elizabeth" uniqKey="Tracey E" first="Elizabeth" last="Tracey">Elizabeth Tracey</name><affiliation wicri:level="1"><nlm:aff id="A18">New South Wales Cancer Registry, Eveleigh, New South Wales, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>New South Wales Cancer Registry, Eveleigh, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Olsen, Jorgen H" sort="Olsen, Jorgen H" uniqKey="Olsen J" first="Jorgen H." last="Olsen">Jorgen H. Olsen</name><affiliation wicri:level="3"><nlm:aff id="A19">Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Pompe Kirn, Vera" sort="Pompe Kirn, Vera" uniqKey="Pompe Kirn V" first="Vera" last="Pompe-Kirn">Vera Pompe-Kirn</name><affiliation wicri:level="1"><nlm:aff id="A20">Cancer Registry of Slovenia, Institute of Oncology, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Cancer Registry of Slovenia, Institute of Oncology, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Brewster, David H" sort="Brewster, David H" uniqKey="Brewster D" first="David H." last="Brewster">David H. Brewster</name><affiliation wicri:level="1"><nlm:aff id="A21">Scottish Cancer Registry, Information Services, NHS National Services Scotland, Edinburgh, Scotland, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Scottish Cancer Registry, Information Services, NHS National Services Scotland, Edinburgh, Scotland</wicri:regionArea><wicri:noRegion>Scotland</wicri:noRegion></affiliation></author><author><name sortKey="Martos, Carmen" sort="Martos, Carmen" uniqKey="Martos C" first="Carmen" last="Martos">Carmen Martos</name><affiliation wicri:level="1"><nlm:aff id="A22">Cancer Registry of Zaragoza, Health Department of Aragon Government, Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Cancer Registry of Zaragoza, Health Department of Aragon Government, Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee-Seng" last="Chia">Kee-Seng Chia</name><affiliation wicri:level="1"><nlm:aff id="A23">Center for Molecular Epidemiology, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Center for Molecular Epidemiology</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Singapore Cancer Registry, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Cancer Registry</wicri:regionArea></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:aff id="A2">International Agency for Research on Cancer (IARC), Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Hashibe, Mia" sort="Hashibe, Mia" uniqKey="Hashibe M" first="Mia" last="Hashibe">Mia Hashibe</name><affiliation wicri:level="3"><nlm:aff id="A2">International Agency for Research on Cancer (IARC), Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A25">University of Utah, School of Medicine, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah, School of Medicine, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Levi, Fabio" sort="Levi, Fabio" uniqKey="Levi F" first="Fabio" last="Levi">Fabio Levi</name><affiliation wicri:level="3"><nlm:aff id="A26">Unité d’épidémiologie du cancer et Registres vaudois et neuchâtelois des tumeurs, Institut de médecine sociale et préventive (IUMSP), Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Unité d’épidémiologie du cancer et Registres vaudois et neuchâtelois des tumeurs, Institut de médecine sociale et préventive (IUMSP), Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name><affiliation wicri:level="3"><nlm:aff id="A1">Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Ricerche Farmacologiche “Mario Negri”, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A27">Dipartimento di Medicina del Lavoro, Sezione di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina del Lavoro, Sezione di Statistica Medica e Biometria, Università degli Studi di Milano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation wicri:level="3"><nlm:aff id="A2">International Agency for Research on Cancer (IARC), Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">International Prevention Research Institute, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Prevention Research Institute, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">International journal of cancer. Journal international du cancer</title><idno type="ISSN">0020-7136</idno><idno type="eISSN">1097-0215</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Scanty data are available on the incidence (i.e., the absolute risk) of second cancers of the head and neck (HN) and its pattern with age. We investigated this issue using data from a multicentric study of 13 population-based cancer registries from Europe, Canada, Australia and Singapore for the years 1943-2000. A total of 99,257 patients had a first primary HN cancer (15,985 tongue, 22,378 mouth, 20,758 pharyngeal, and 40,190 laryngeal cancer), contributing to 489,855 person-years of follow-up. 1294 of the patients (1.3%) were diagnosed with second HN cancers (342 tongue, 345 mouth, 418 pharynx, and 189 larynx). Male incidence rates of first HN cancer steeply increased from 0.68/100,000 at age 30-34 to 46.2/100,000 at age 70-74, and leveled off at higher age; female incidence increased from 0.50/100,000 at age 30-34 to 16.5/100,000 at age 80-84. However, age-specific incidence of second HN cancers after a first HN cancer in men was around 200-300/100,000 between age 40-44 and age 70-74, and tended to decline at subsequent ages (150/100,000 at age 80-84); in women, incidence of second HN cancers was around 200-300/100,000 between age 45-49 and 80-84. The patterns of age-specific incidence were consistent for different subsites of second HN cancer and sexes; moreover, they were similar for age-specific incidence of first primary HN cancer in patients who subsequently developed a second HN cancer. The incidence of second HN cancers does not increase with age, but remains constant, or if anything, decreases with advancing age.</p><sec id="S1"><title>Impact statement</title><p id="P2">While the incidence of first primary cancers of the head and neck increases with advancing age that of second primary cancers is stable between age 40 and 70 and, if anything, declines thereafter.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Islande</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>Singapour</li><li>Slovénie</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Canton de Vaud</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Hovedstaden</li><li>Lombardie</li><li>Manitoba</li><li>Rhône-Alpes</li><li>Svealand</li><li>Utah</li><li>État de New York</li></region><settlement><li>Copenhague</li><li>Heidelberg</li><li>Lausanne</li><li>Londres</li><li>Lyon</li><li>Milan</li><li>Stockholm</li><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Bosetti, Cristina" sort="Bosetti, Cristina" uniqKey="Bosetti C" first="Cristina" last="Bosetti">Cristina Bosetti</name></region><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name><name sortKey="La Vecchia, Carlo" sort="La Vecchia, Carlo" uniqKey="La Vecchia C" first="Carlo" last="La Vecchia">Carlo La Vecchia</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name></region><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><name sortKey="Chuang, Shu Chun" sort="Chuang, Shu Chun" uniqKey="Chuang S" first="Shu-Chun" last="Chuang">Shu-Chun Chuang</name><name sortKey="Hashibe, Mia" sort="Hashibe, Mia" uniqKey="Hashibe M" first="Mia" last="Hashibe">Mia Hashibe</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Chuang, Shu Chun" sort="Chuang, Shu Chun" uniqKey="Chuang S" first="Shu-Chun" last="Chuang">Shu-Chun Chuang</name></region><name sortKey="Brewster, David H" sort="Brewster, David H" uniqKey="Brewster D" first="David H." last="Brewster">David H. Brewster</name></country><country name="Canada"><noRegion><name sortKey="Tonita, Jon M" sort="Tonita, Jon M" uniqKey="Tonita J" first="Jon M." last="Tonita">Jon M. Tonita</name></noRegion><name sortKey="Kliewer, Erich V" sort="Kliewer, Erich V" uniqKey="Kliewer E" first="Erich V." last="Kliewer">Erich V. Kliewer</name><name sortKey="Kliewer, Erich V" sort="Kliewer, Erich V" uniqKey="Kliewer E" first="Erich V." last="Kliewer">Erich V. Kliewer</name><name sortKey="Kliewer, Erich V" sort="Kliewer, Erich V" uniqKey="Kliewer E" first="Erich V." last="Kliewer">Erich V. Kliewer</name><name sortKey="Tamaro, Sharon" sort="Tamaro, Sharon" uniqKey="Tamaro S" first="Sharon" last="Tamaro">Sharon Tamaro</name></country><country name="Islande"><noRegion><name sortKey="Jonasson, Jon G" sort="Jonasson, Jon G" uniqKey="Jonasson J" first="Jon G." last="Jonasson">Jon G. Jonasson</name></noRegion><name sortKey="Jonasson, Jon G" sort="Jonasson, Jon G" uniqKey="Jonasson J" first="Jon G." last="Jonasson">Jon G. Jonasson</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Hemminki, Kari" sort="Hemminki, Kari" uniqKey="Hemminki K" first="Kari" last="Hemminki">Kari Hemminki</name></region></country><country name="Suède"><noRegion><name sortKey="Hemminki, Kari" sort="Hemminki, Kari" uniqKey="Hemminki K" first="Kari" last="Hemminki">Kari Hemminki</name></noRegion><name sortKey="Hemminki, Kari" sort="Hemminki, Kari" uniqKey="Hemminki K" first="Kari" last="Hemminki">Kari Hemminki</name><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></country><country name="Norvège"><noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></noRegion><name sortKey="Pukkala, Eero" sort="Pukkala, Eero" uniqKey="Pukkala E" first="Eero" last="Pukkala">Eero Pukkala</name><name sortKey="Pukkala, Eero" sort="Pukkala, Eero" uniqKey="Pukkala E" first="Eero" last="Pukkala">Eero Pukkala</name></country><country name="Australie"><noRegion><name sortKey="Tracey, Elizabeth" sort="Tracey, Elizabeth" uniqKey="Tracey E" first="Elizabeth" last="Tracey">Elizabeth Tracey</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Olsen, Jorgen H" sort="Olsen, Jorgen H" uniqKey="Olsen J" first="Jorgen H." last="Olsen">Jorgen H. Olsen</name></region></country><country name="Slovénie"><noRegion><name sortKey="Pompe Kirn, Vera" sort="Pompe Kirn, Vera" uniqKey="Pompe Kirn V" first="Vera" last="Pompe-Kirn">Vera Pompe-Kirn</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Martos, Carmen" sort="Martos, Carmen" uniqKey="Martos C" first="Carmen" last="Martos">Carmen Martos</name></noRegion></country><country name="Singapour"><noRegion><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee-Seng" last="Chia">Kee-Seng Chia</name></noRegion><name sortKey="Chia, Kee Seng" sort="Chia, Kee Seng" uniqKey="Chia K" first="Kee-Seng" last="Chia">Kee-Seng Chia</name></country><country name="États-Unis"><region name="Utah"><name sortKey="Hashibe, Mia" sort="Hashibe, Mia" uniqKey="Hashibe M" first="Mia" last="Hashibe">Mia Hashibe</name></region><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Levi, Fabio" sort="Levi, Fabio" uniqKey="Levi F" first="Fabio" last="Levi">Fabio Levi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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